Selected Publications
Total citations: >35,000 (by December 2024)
Six publications, each receiving >2,000 citations (with five each surpassing 3,000), are linked to Google Scholar.
Highlighted publications
Cell entry mechanisms of SARS-CoV-2.
Shang, J. et al., PNAS, 2020, [PDF], [Web], [PubMed], [Google Scholar]
Structural basis of receptor recognition by SARS-CoV-2.
Shang, J. et al., Nature, 2020, [PDF], [Web], [PubMed], [Google Scholar]
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.
Li, F. et al., Science, 2005, [PDF], [Web], [PubMed], [Google Scholar]
Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-Long structural studies of SARS coronavirus.
Wan, Y. et al., Journal of Virology, 2020, [PDF], [Web], [PubMed], [Google Scholar]
Structure, function, and evolution of coronavirus spike proteins.
Li, F., Annual Review of Virology, 2016, [PDF], [Web], [PubMed], [Google Scholar]
Origin and evolution of pathogenic coronaviruses.
Cui, J. et al., Nature Reviews Microbiology, 2019, [PDF], [Web], [PubMed], [Google Scholar]
Molecular mechanisms of SARS-CoV-2
Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant.
Zhang, W. et al., PNAS, 2022, [PDF], [Web], [PubMed]
Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses.
Zhang, W. et al., PNAS, 2024, [PDF], [Web], [PubMed]
Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomain.
Ye, G. et al., Nature Communications, 2022, [PDF], [Web], [PubMed]
Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein.
Geng, Q. et al., eLife, 2023, [PDF], [Web], [PubMed]
Molecular mechanisms of other coronaviruses
Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus.
Yang, Y. et al., PNAS, 2014, [PDF], [Web], [PubMed]
Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor.
Peng, G. et al., PNAS, 2011, [PDF], [Web], [PubMed]
Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor.
Wu, K. et al., PNAS, 2009, [PDF], [Web], [PubMed]
Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry.
Shang, J. et al., PLOS Pathogens, 2020, [PDF], [Web], [PubMed]
Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins.
Shang, J. et al., PLOS Pathogens, 2018, [PDF], [Web], [PubMed]
Molecular mechanism for antibody-dependent enhancement of coronavirus entry.
Wan, Y. et al., Journal of Virology, 2020, [PDF], [Web], [PubMed]
Receptor recognition mechanisms of coronaviruses: a decade of structural studies.
Li, F., Journal of Virology, 2015, [PDF], [Web], [PubMed]
Intervention strategies against coronavirus infections
Structure-guided in vitro evolution of nanobodies targeting new viral variants.
Ye, G. et al., PLOS Pathogens, 2024, [PDF], [Web], [PubMed]
Discovery of Nanosota-9 as anti-Omicron nanobody therapeutic candidate.
Ye, G. et al., PLOS Pathogens, 2024, [PDF], [Web], [PubMed]
Dual-role epitope on SARS-CoV-2 spike enhances and neutralizes viral entry across different variants.
Ye, G. et al., PLOS Pathogens, 2024, [PDF], [Web], [PubMed]
Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19.
Ye, G. et al., Journal of Virology, 2023, [PDF], [Web], [PubMed]
The Development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates.
Ye, G. et al., eLife, 2021, [PDF], [Web], [PubMed]
Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection.
Geng, Q. et al., PLOS Pathogens, 2021, [PDF], [Web], [PubMed]
Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines.
Du, L. et al., Nature Communications, 2016, [PDF], [Web], [PubMed]
Molecular mechanisms and intervention strategies against filoviruses
Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1.
Bu, F. et al., Communications Biology, 2025, [PDF], [Web], [PubMed]
Discovery of Nanosota-EB1 and -EB2 as Novel Nanobody Inhibitors Against Ebola Virus Infection.
Bu, F. et al., PLOS Pathogens, 2024, [PDF], [Web], [PubMed]
Molecular mechanisms and intervention strategies against other human diseases
Structural basis for multifunctional roles of mammalian aminopeptidase N.
Chen, L. et al., PNAS, 2012, [PDF], [Web], [PubMed]
A unified mechanism for aminopeptidase N-based tumor cell motility and tumor-homing therapy.
Liu, C. et al., Journal of Biological Chemistry, 2014, [PDF], [Web], [PubMed]
Structural insights into central hypertension regulation by human aminopeptidase A.
Yang, Y. et al. Journal of Biological Chemistry, 2013, [PDF], [Web], [PubMed]
Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP.
Li, F. et al., Cell, 2002, [PDF], [Web], [PubMed]